TrueNAS on Proxmox, good idea?

Hi,
my initial idea was to configure my F4-424 Max as a new homeserver as following:
- 2 NVME SSDs used for OS, containers and VMs
- 4 HDDs used by a virtualized NAS OS like OMV or TrueNAS via PASSTHROUGH and configured as RAID5

In general, do you think it is a good idea to virtualize a NAS OS + PASSTHROUGH (HDDs) from a technical point of view concerning reliability, maintenance, configuration, failure case, etc?

Regards Pete