Best Practices for File System Alignment in Virtual Environments

Dear members

I would like to set up my server with Proxmox VE. I want to install the Proxmox host on a separate system disk (Samsung 860 500GB) and create a ZFS Raid 10 pool on 4 x 2TB Samsung 860 for my VMs.

My question is: How can I get the correct hard drive alignment and perfect performance? The sector alignment is apparently very important for optimal I / O performance.

Thank you and best regards
Marko