Proxmox on NVMe vs. SATA SSD

I am building a homelab on a Qotom Q20331G9. System board has two onboard PCIe 3.0 x2 M.2 and two onboard SATA plus a SFF8087 port. I want to play with a virtualized instance of TrueNAS and would eventually like to configure it with SSD caching. I am looking for opinions on how to best configure the system.

Should I put Prox OS + VMs on NVMe and using SATA SSDs for TrueNAS metadata/cache. Or should I put OS + VMs on SATA and use the NVMe for TrueNAS? Initially I will have just two...

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