Converting machine to Proxmox VE server

Hello,

Wanted to ask for suggestions. I'm planning to convert machine with following specs to Proxmox VE server:

CPU: AMD Ryzen 9 5900X
RAM: DDR 4, 32GB
Drives:

• nVme - 500GB
• SSD - 500GB
• HDD 2.5' - 1TB
• HDD 3.5' - 2TB
• HDD 3.5' - 4TB

Initial ideas was to try and use ZFS as I'm really interested to learn how it works (self-healing, deduplication) but going through forum I learned that it's not great idea if you don't have similar drive's size to make any kind of RAID...

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